Hormones and Lung Maturation

Produktbeschreibung

As I reflect on the evolution of this book, I am struck by the differences be tween my early conceptions and the final product. When I was first ap proached by Springer-Verlag regarding a monograph on my interests in the area of fetal lung development, I imagined that it would be relatively easy to summarize my contributions, plus the work of other investigators as needed for proper perspective. This rather naive idea was abandoned as I prepared my initial outlines for the monograph. I quickly realized that con tributions from my laboratory are not sufficient for telling the story of "hormones and lung maturation". The result of this decision is a longer and more heavily-referenced book than I originally envisioned. Although I have attempted to discuss in considerable detail most aspects of hormones and the fetal lung, I know with certainty that I have not in cluded all relevant references in each area. In most of these instances this reflects my impatience or lack of diligence, and I offer my apologies to those investigators whose work has been so omitted. In some situations published work has not been cited in a deliberate decision to limit the breadth of discussion or, rarely, due to my judgment of major shortcom ings in experimental design or execution. 

Inhaltsverzeichnis

1 Lung Development.- 1.1 Introduction.- 1.2 Structural Development.- 1.3 The Surfactant System.- References.- 2 Glucocorticoid Effects in Vivo.- 2.1 Historical Perspective.- 2.2 Experimental Approaches.- 2.3 Morphology.- 2.4 Alveolar Surfactant.- 2.5 Pulmonary Function and Viability.- 2.6 Biochemical Effects.- 2.7 Responses in Other Tissues.- 2.8 Effect of Gender.- 2.9 Summary.- References.- 3 Glucocorticoid Receptor.- 3.1 General Properties.- 3.2 Specific Properties.- 3.3 Evidence for Receptor Mediation of Corticosteroid Effects.- 3.4 Summary and Conclusions.- References.- 4 Role of Endogenous Corticosteroids.- 4.1 Temporal Associations.- 4.2 Experimental Manipulations.- 4.3 Sources of Increased Corticosteroids.- 4.4 Clinical Evidence.- 4.5 Summary and Conclusion.- References.- 5 Antenatal Glucocorticoid Therapy: Clinical Effects.- 5.1 Respiratory Distress Syndrome.- 5.2 Prevention of RDS: Factors Influencing Efficacy of Therapy.- 5.3 Other Effects of Therapy.- 5.4 Follow-up After Glucocorticoid Therapy.- 5.5 Summary.- References.- 6 Antenatal Glucocorticoid Therapy: Hormone Concentrations.- 6.1 Concentration of Administered Corticosteroids.- 6.2 Suppression of Endogenous Cortisol.- 6.3 Glucocorticoid Activity in Fetal Plasma.- 6.4 Effect on Other Endogenous Hormones.- 6.5 Summary and Conclusions.- References.- 7 Thyroid Hormones: Effects and Binding.- 7.1 Effects in Vivo.- 7.2 Uptake and Metabolism.- 7.3 Nuclear T3 Receptor.- 7.4 Effects in Culture.- 7.5 Human Studies.- 7.6 Conclusions.- References.- 8 Beta-Adrenergic Agonists.- 8.1 Effects.- 8.2 Receptor.- 8.3 Conclusions and Perspectives.- References.- 9 Other Hormones.- 9.1 Prolactin.- 9.2 Estradiol.- 9.3 Epidermal Growth Factor.- 9.4 Thyrotropin-Releasing Hormone.- 9.5 Fibroblast Pneumonocyte Factor.- 9.6 Insulin.- References.- 10 Hormone Interactions.- 10.1 Thyroid Hormones and Corticosteroids.- 10.2 cAMP and Glucocorticoids.- 10.3 cAMP and T3.- 10.4 Multi-Hormonal Regulation: An Overview.- 10.5 Combined Hormone Therapy.- References.